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pentobarbital will lessen the level or influence of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will decrease the level or impact of irinotecan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.Reserve concomitant prescribing of such drugs in clients for w